Cosmetic and/or pharmaceutical preparations

ABSTRACT

The invention relates to cosmetic and/or pharmaceutical preparations containing (a) water soluble β-(1,3) glucans that are substantially devoid of β-(1,6) links, and (b) deoxyribonucleic acids and their breakdown and degradation products.

This is the National Phase Application of PCT/EP00/01838 filed Mar. 3,2000.

FIELD OF THE INVENTION

The invention is situated in the area of cosmetics and concernspreparations containing mixtures of specific glucans and nucleic acids.

PRIOR ART

The pigment coating of normal skin leads under the influence of sunradiation to the formation of melanines. In this connection theirradiation with UV-A light with long wavelength leads to darkening ofthe melanine bodies which are already in the epidermis, without visibleharmful results, whereas the UV-B radiation with short wavelengths leadsto formation of new melanines. However, prior to the formation of theprotective pigment, the skin is exposed to the influence of theunfiltered radiation, which, depending of exposure time, leads to redskin (erythemas), inflammation of the skin (sunburn) or also to blistersof bum. The stress on the organism in connection with such skin lesions,e.g. in connection with the distribution of histamines, can in additionlead to headache, faintness, fever, disturbance of heart and circulationand such like. For the consumer who wants to protect himself against theharmful aspects of radiation from the sun, various products are offeredon the market, in the form of preparations in water and also cremes,oils and milky emulsions, which in addition to some skin care substancesmainly contain UV light protection filters. However, as to the UVprotection as well as the support of the regulation of the water andmetabolism in the epidermis, these preparations are by no meanssatisfactory.

Therefore there is in still a demand in the market for products with animproved spectrum of efficiency. For the evaluation of the efficiency ofsuch products it is above all relevant, to what extent they are capableof preventing the harmful effects of the UV radiation to the skin andhair, especially, however, to the (desoxy)ribonucleic acids of the skin.Further skin compatibility as well as the use of natural products, arein demand by the customer.

In this connection reference is made to the European patent EP-B10500718, as well as patents U.S. Pat. Nos. 4,891,220; 5,223,491;5,397,773; 5,519,009; 5,576,015, 5,702,719 and 5,705,184 (Donzis), fromwhich the use of glucans in skin care and sun protecting agents isknown. The glucans are obtained through extraction from the cell wallsof yeasts, they are insoluble in water and contain (1,6) linkages.Further in EP-A1 0681830 (Unilever) sun protection agents are suggestedwhich contain ethylene/vinyl acetate copolymers and polyacrylates, UVlight protection filters and optionally up to 10% by weight of glucans.Eventually, from U.S. Pat. No. 5,158,772 (Davis) compositions for thetopical use on the skin are known, which among others contain aneffective amount of a specific 1,3 glucan, which is obtained fromCellulomonas flavigena.

Further, reference is made to the French patent application FR-A12511253, in which skin and sun protection agents with a content of DNAand with a high degree of polymerisation are suggested. From theJapanese laid open publication JP-A2 621096404 (Kanebo) cosmeticpreparations with nucleic acids and diisopropylamin dichloro acetate areknown. The object of the French patent FR-B1 2620024 (Soc. d'EtudesDermatologiques) are preparations containing nucleic acid derivatives asradical capturers. Examples are adenine, guanosin, xanthin, hypoxanthin,uracil and ribonucleic acid. In the international patent application WO95/01773 (Boston University) a method for stimulating the pigmentproduction is described, wherein DNA fragments are transported inliposomal form in the epidermis. Finally, the object of the Germanpatent application DE-A1 4323615 is compositions with a content ofnucleic acids and their fragments as anti wrinkling creme and sunprotection creme.

Consequently, the complex task of the present invention was to makeavailable cosmetic, respectively pharmaceutical, preparations, which bytopical use penetrate the upper layers of the skin, or by hair carepenetrate the keratin fibers, where they protect the tissue as well asthe cells in a direct manner against the harmful effects of UVradiation, and support the film formation on the hair and the regulationof the water and the metabolic functions in the skin, and in this wayare causing a vitalisation.

DESCRIPTION OF THE INVENTION

The object of the invention is cosmetic and/or pharmaceuticalpreparations which contain

(a) water soluble β-(1,3) glucans, substantially free from β-(1,6)linkages, and

(b) (desoxy)ribonucleic acids, as well as their cleavage and degradationproducts.

Surprisingly it was found that mixtures of β-(1,3) glucans, which aresubstantially free from β-(1,6) linkages, together with ribo- or desoxyribonucleic acids show a synergistic improved absorption spectrum, whichis especially well suited for protection of (desoxy)ribonucleic acids ofthe body. This effect, which has not been found in mixtures of nucleicacids with glucans, which still show appreciable fractions of (1,6)branches, can advantageously be increased by using as further componentscommon UV light protection factors or antioxydants, which may be organicfilters or anorganic pigments. The preparations according to theinvention are further distinguished by the fact that they moderate skinirritations and injuries and stimulate the water and metabolicprocedures in the skin, so that for example also the wrinkling becauseof desiccating due to heavy radiation from the sun at the same time iscounteracted. As to the hair the film formation is supported.

Water Soluble β-(1,3) Glucans

The term glucans is intended to mean homopolysaccharides based onglucose. Depending on sterical linking there is a difference betweenβ-(1,3), β-(1,4) and β-(1,6) glucans. β-(1,3) Glucans normally show ahelical structure, whereas glucans with a (1,4) linkage generally have alinear structure. The β-glucans of the invention have a (1,3) structure,i.e. they are substantillay free from undesired (1,6) linkages.Preferably such β-(1,3) glucans are used where the side chainsexclusively show (1,3) linkages. Especially the agents contain glucanswhich are obtained on the basis of yeast from the family Sacchaomyces,especially Saccharomyces cerevisiae. Glucans of this type are availablein technical amounts according to known methods. The Internationalpatent application WO 95/30022 (Biotec-Mackzymal) describes e.g. amethod for producing such substances, wherein glucans with β-(1,3) andβ-(1,6) linkages are brought in contact with β-(1,6) glucanases in sucha way, that practically all β-(1,6) linkages are loosened. Preferablyused for the manufacture of these glucans are glucanases based onTrichodermia harzianum. As to the manufacture and availability of theglucans contained in these agents, reference is made to the above citedpublication.

(Desoxy)ribonucleic Acids

As (desoxy)ribonucleic acids (DNA or RNA) is to be understood highmolecular, thread-like polynucleotides, which are derived from2′-desoxy-β-D-ribonucleosides or D-ribonucleosides, which again arebuilt up of equivalent amounts of a nucleobase and pentose2-desoxy-D-ribofuranose or D-ribofuranose. As nucleobases the DNA's orRNA's may contain the purine derivatives adenine and guanine as well asthe pyrimidines cytosine and thymine or uracil. In the nucleic acids thenucleobases are N-glycosidic with the carbon atom 1 of the ribose,whereby in each individual case adenosine, guanosine, cytidine andthimidine developes. In the acids a phosphate group is connecting the5′-hydroxy groups of the nucleosides with der 3′-OH group of the in eachcase following through a phosphodiester bridge under formation of singlestring DNA or RNA. Because of the high ratio of length to diameter DNA,respectively RNA, molecules tend to a string break already by mechanicalstrain, such as during the extraction. Therefore the molecular weight ofthe nucleic acids may be from 10³ to 10⁹ Daltons. For the purpose of theinvention concentrated DNA or RNA solutions are used, which arecharacterised by a liqid-crystalline behaviour. Preferably desoxy orribonucleic acids are used, which are obtained from marine sources forexample through extraction of fish sperm and which have a molecularweight in the area from 40 000 to 1 000 000 Daltons. The nucleic acidsmay thereby be present in helical form and also as separate strings aswell as their fragments. Especially preferable is the use of desoxyribonucleic acids of marine origin with a molecular weight in the areafrom 50 000 to 100 000 Daltons.

In a preferable embodiment of the present invention the preparationscontain

(a) 0.01 to 25, preferably 0.5 to 15 and especially 1 to 5% by weight ofwater soluble β-(1,3) glucans, which are substantially free from β-(1,6)linkages,

(b) 0.01 to 5, preferably 0.05 to 3 and especially 0.5 to 1% by weightof (desoxy)ribonucleic acid as well its cleavage and decompositionproducts, and

(c) 0 to 8, preferably 0.5 to 5 and especially 1 to 3% by weight of UVlight protection factors, respectively antioxidants provided that thestated amounts are supplemented with water as well as possibly otherauxiliaries and additional agents up to 100% by weight.

Commercial Applicability

The preparations according to the invention, for example, care agentsfor skin and hair, sun protection agents and, can e.g. be in the form ofsolutions, lotions, cremes, oils, gels, sticks and such like, and mayfurther contain as additional auxiliary and additional agents mildsurfactants, oil bodies, emulsifiers, hyperfatting agents, pearl lustrewaxes, consistency substances, thickening agents, polymers, siliconecompounds, fats, waxes, stabilizing agents, biogenic active substances,deodorants, agents against dandruff, film forming agents, swellingagents, antioxidants, inorganic colour pigments, hydrotropes,preservatives, insect repellents, self tanning agents, solubilizingagents, perfume oils, colouring agents and such like.

Typical examples of suitable mild, i.e. especially skin compatiblesurfactants. are fatty alcohol polyglycol ether sulphates, monoglyceridesulphates, mono- and/or dialkyl sulfosuccinates, fatty acidisethionates, fatty acid sarcosinates, fatty acid taurides, fatty acidglutamates, α-olefine sulphonates, ethercarboxylic acids, alkyloligoglucosides, fatty acid glucamides, alkylamido betaines and/orprotein fatty acid condensates, the last mentioned preferably based onwheat proteins.

As oil bodies use can be made of for example Guerbet alcohols based onfatty alcohols with 6 to 18, preferably 8 to 10 carbon atoms, esters oflinear C₆-C₂₂ fatty acids with linear C₆-C₂₂ fatty alcohols, esters ofbranched C₆-C₁₃ carboxylic acids with linear C₆-C₂₂ fatty alcohols, suchas e.g. myristyl myristate, myristyl palmitate, myristyl stearate,myristyl isostearate, myristyl oleate, myristyl behenate, myristylerucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetylisostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearylmyristate, stearyl palmitate, stearyl stearate, stearyl isostearate,stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate,isostearyl palmitate, isostearyl stearate, isostearyl isostearate,isostearyl oleate, isosteayl behenate, isostearyl oleate, oleylmyristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyloleate, oleyl behenate, oleyl erucate, behenyl myristate, behenylpalmitate, behenyl stearate, behenyl isostearate, behenyl oleate,behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate,erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate anderucyl erucate. In additon esters of linear C₆-C₂₂ fatty acids withbranched alcohols, especially 2-ethylhexanol, esters ofhydroxycarboxylic acids with linear or branched C₆-C₂₂ fatty alcohols,especially dioctyl malate, esters of linear and/or branched fatty acidswith polyvalent alcohols (such as e.g. propylene glycol, dimeric diol ortrimeric triol) and/or Guerbet alcohols, triglycerides based on C₆-C₁₀fatty acids, liquid mixtures of mono-/di-/triglycerides based on C₆-C₁₈fatty acids, esters of C₆-C₂₂ fatty alcohols and/or Guerbet alcoholswith aromatic carboxylic acids, especially benzoic acid, esters ofC₂-C₁₂ dicarboxylic acids with linear or branched alcohols with 1 to 22carbon atoms or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxylgroups, plant oils, branched primary alcohols, substituted cyclohexanes,linear and branched C₆-C₂₂ fatty alcohol carbonates, Guerbet carbonates,esters of benzoic acid with linear and/or branched C₆-C₂₂ alcohols (e.g.Finsolv®TN), linear or branched, symmetrical or unsymmetrical dialkylethers with 6 to 22 carbon atoms in each alkyl group, ring openingproducts of epoxydated fatty acid esters with polyols, silicone oilsand/or aliphatic or naphthenic hydrocarbons, such as e.g. squalan,squalen or dialkyl cyclohexanes, can be used

As emulsifiers for example nonionic surfactants from at least one of thefollowing groups may be used:

(1) Addition products of 2 to 30 moles ethylene oxide and/or 0 to 5moles propylene oxide on linear fatty alcohols with 8 to 22 C atoms, onfatty acids with 12 to 22 C atoms and on alkyl phenols with 8 to 15 Catoms in the alkyl group;

(2) C_(12/18) fatty acid mono- and -diesters of addition products of 1to 30 moles ethylene oxide and glycerol;

(3) glycerol mono- and diesters and sorbitan mono- and diesters ofsaturated and unsaturated fatty acids with 6 to 22 carbon atoms andtheir ethylene oxide addition products;

(4) alkyl mono- and oligoglycosides with 8 to 22 carbon atoms in thealkyl group and their ethoxylated analogues;

(5) addition products of 15 to 60 moles ethylene oxide on ricinus oiland/or hardened ricinus oil;

(6) polyol and especially polyglycerol esters, such as e.g. polyglycerolpolyricinoleate, polyglycerol poly-12-hydroxystearate or polyglyceroldimerate isostearate, and also mixtures of compounds from more of theseclasses of substances;

(7) addition products of 2 to 1 5 moles ethylene oxide on ricinus oiland/or hardened ricinus oil;

(8) partial esters based on linear, branched, unsaturated or saturatedC_(6/22) fatty acids, ricinolic acid and 12-hydroxy stearic acid andglycerol, polyglycerol, pentaerythrite, dipentaerythrite, sugar alcohols(e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butylglucoside, lauryl glucoside) as well as polyglucosides (e.g. cellulose);

(9) mono-, di- and trialkylphosphates as well as mono-, di- and/ortri-PEG alkylphosphates and their salts;

(10) wool wax alcohols;

(11) polysiloxane/polyalkyl/polyether copolymers or correspondingderivatives;

(12) mixed esters of pentaerythrite, fatty acids, citric acid and fattyalcohol according to DE 1165574 PS and/or mixed esters of fatty acidswith 6 to 22 carbon atoms, methyl glucose and polyols, preferablyglycerol or polyglycerol,

(13) polyalkylene glycols, as well as

(14) glycerol carbonate.

The addition products of ethylene oxide and/or of propylene oxide onfatty alcohols, fatty acids, alkyl phenols, glycerol mono- and diestersas well as sorbitan mono- and -diesters of fatty acids or on ricinus oilare known products which are commercially available. They are mixturesof homologous substances, with average degree of alkoxylationcorresponding to the ratio of the amounts of the substances ethyleneoxide and/or propylen oxide and substrate, with which the additionreaction is carried out. C_(12/18) fatty acid mono- and -diesters ofaddition products of ethylene oxide on glycerol are known from DE2024051 PS as revertive fatting agents for cosmetic preparations.

C_(8/18) alkyl mono- and oligoglycosides, their manufacture and theiruse is known from prior art. Their preparation can especially be carriedout by reaction of glucose or oligosaccharides with primary alcoholshaving 8 to 18 C atoms. With regard to the glycoside residue bothmonoglycosides, where a cyclic sugar group is glycosidic bond to thefatty alcohol, and oligomeric glycosides with a degree ofoligomerisation until preferably about 8, are suitable. The degree ofoligomerization is then a statistical mean value, based on adistribution of homologues which is usual for such products of technicalquality.

Zwitterionic surfactants can also be used as emulsifiers. The termzwitterionic surfactants is intended to mean such surface activecompounds which in their molecule have at least a quatenary ammoniumgroup and at least one carboxylate and one sulphonate group. Especiallysuitable zwitterionic surfactants are the so-called betaines such as theN-alkyl-N,N-dimethyl ammonium glycinates, for example the cocoalkyldimethyl ammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinate, for example the coco acylaminopropyl dimethylammonium glycinate, and 2-alkyl-3-carboxylmethylhydroxyethyl imidazolinewith in each case 8 to 18 C atoms in the alkyl or acyl- groups, as wellas the coco acylaminoethyl hydroxyethylcarboxymethyl glycinate.Especially preferred is that under the CTFA term cocamidopropyl betaineknown fatty acid amide derivative. Also suitable emulsifiers areampholytic surfactants. Ampholytic surfactants are such surface activecompounds which in additon to a C_(8/18) alkyl or acyl group in themolecule at least contain a free amino group and at least one —COOH or—SO₃H group and which can form inner salts. Examples of suitableampholytic surfactants are N-alkyl glycines, N-alkyl propionic acids,N-alkyl aminobutyric acids, N-alkyl iminodipropionic acids,N-hydroxyethyl-N-alkylamidopropyl glycines, N-alkyltaurines,N-alkylsarcosines, 2-alkylaminopropionic acids and alkylamino aceticacids with in each case about 8 to 18 C atoms in the alkyl group.Especially preferable ampholytic surfactants are the N-coco alkylaminopropionate, the coco acylamino ethylaminopropionate and the C_(12/18)acylsarcosine. In addition to the ampholytic, also quaternaryemulsifiers can be used, of which ester salts of the type of esterquats,preferably methylquaternised di-fatty acid triethanolamine ester salts,are especially preferable.

As hyperfatting agents substances such as for example lanolin andlecithin as well as polyethoxylated or acylated lanolin and lecithinderivatives, polyol fatty acid esters, monoglycerides and fatty acidalkanolamides can be used, whereby the last mentioned at the same timeact as foam stabilisers.

As exemplary pearl gloss waxes the following should be mentioned:Alkylene glycolester, especially ethyleneglycol distearate; fatty acidalkanolamides, especially coco fatty acid diethanolamide; partialglycerides, especially stearic acid monoglyceride; esters of polyvalent,possibly hydroxysubstituted carboxylic acids with fatty alcohols with 6to 22 carbon atoms, especially long chain esters of tartaric acid; fatsubstances, such as for example fatty alcohols, fatty ketones, fattyaldehydes, fatty ethers and fatty carbonates, wherein the sum of carbonatoms is at least 24, especially lauron and distearyl ethers; fattyacids such as stearic acid, hydroxystearic acid or behenic acid, ringopening products of olefine epoxides with 12 to 22 carbon atoms withfatty alcohols with 12 to 22 carbon atoms and/or polyols with 2 to 15carbon atoms and 2 to 10 hydroxyl groups as well as their mixtures.

As consistency givers preferably use is made of fatty alcohols orhydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbonatoms and additionally partial glycerides, fatty acids or hydroxy fattyacids. A combination of these substances with alkyl oligoglucosidesand/or fatty acid-N-methyl glucamides with the same chain length and/orpolyglycerol-poly-12-hydroxy stearates.

Suitable thickening agents are for example types of aerosil (hydrophilicsilicic acids), polysaccharides, especially xanthan gum, guar-guar,agar-agar, alginates and tyloses, carboxymethyl celluloses andhydroxyethyl celluloses, as well as higher molecular polyethylenglycolmono- and diesters of fatty acids. polyacrylates, (e.g. Carbopols® fromGoodrich or Synthalenes® from Sigma), poly-acrylamides, polyvinylalcohol and polyvinyl pyrrolidone, surfactants such as for exampleethoxylated fatty acid glycerides, ester of fatty acids with polyolssuch as for example pentaerythrite or trimethylolpropane, fatty alcoholethoxytates with narrow distribution of homologous or alkyloligoglucosides as well as elektrolytes such as sodium chloride andammonium chloride.

Suitable cationic polymers are for example cationic cellulosederivatives, such as e.g. a quaternized hydroxyethyl cellulose, which isavailable under the name of Polymer JR 400® from Amerchol, cationicstarch, copolymers of diallyl ammonium salts and acrylamides,quaternized vinylpyrrolidone/vinylimidazol polymers, such as e.g.Luviquat® (BASF), condensation products of polyglycols and amines,quaternized collagen polypeptides, such as for example lauryl dimoniumhydroxypropyl hydrolyzed collagen (Lamequat® L/Grünau), quaternizedwheat polypeptides, polyethyleneimine, cationic silicone polymers, suchas e.g. amidomethicones, copolymers of adipic acid and dimethylaminohydroxypropyl diethylenetriamine (Cartaretine®/Sandoz), copolymers ofacrylic acid with dimethyl diallylammonium chloride (Merquat®550/Chemviron), polyamino polyamides, such as e.g. described in FR2252840 A, as well as their cross-linked water soluble polymers, catonicchitin derivatives such as for example quaternized chitosane, possiblymicro crystalline distributed, condensation products of dihalogenalkyls, such as e.g. dibromobutane with bisdialkylamines, such as e.g.bis-dimethylamino-1,3-propane, cationic guar-gum, such as e.g. Jaguar®CBS, Jaguars® C-17, Jaguar® C-16 from Celanese, quaternised ammoniumsalt polymers, such as e.g. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1from Miranol.

As exemplary anionic, zwitterionic, amphoteric and non-ionic polymersthe following can be used: Vinyl acetate/crotonic acid copolymers, vinylpyrrolidone/vinyl acrylate copolymers, vinyl acetate/butylmaleate/isobornyl acrylate copolymers, methyl vinylether/maleic acidanhydride copolymers and their esters, non-cross-linked and with polyolscross-linked polyacrylic acids, acrylamido propyltrimethyl ammoniumchloride/acrylate copolymers, octylacrylamide/methylmethacrylate/tert.-butylaminoethyl methacrylate/2-hydroxypropylmethacrylate copolymers, polyvinylpyrrolidone,vinylpyrrolidone/vinylacetate copolymers, vinylpyrrolidon/dimethylaminoethylmethacrylate/vinyl caprolactam terpolymers as well as possiblyderivatized cellulose ethers and silicones.

Suitable silicon compounds are for example dimethyl polysiloxane,methylphenyl polysiloxane, cyclic silicones as well as amino, fattyacid, alcohol, polyether, epoxy, fluorine, glykoside and/or alkylmodified silicon compounds, which at room temperature can be in theliquid as well as in the resin state. Further suitable are simethicones,which are mixtures of dimethicones with an average chain length of 200to 300 dimethyl siloxane units and hydrogenated silicates. A detailedsurvey of suitable volatile silicones can also be found in Todd et al.,Cosm.Toil. 91, 27(1976).

Typical exemplary fats are glycerides, and as waxes natural waxes amongothers, can be used, such as e.g. candelilla wax, carnauba wax, Japanwax, espartogras wax, cork wax, guaruma wax, rice seed oil wax, sugarcane wax, ouricury wax, montan wax, beeswax, schellak wax, spermaceti,lanolin (wool wax), burzel fat, ceresin, ozokerit (terrestrial wax),petrolatum, paraffin waxes, micro waxes; chemically modified waxes (hardwaxes), such as e.g. montanester waxes, sasot waxes, hydrogenated yoyobawaxes as well as synthetic waxes, such as e.g. polyalkylene waxes andpolyethylene glycol waxes.

As stabilizers metal salts of fatty acids, such as e.g. magnesium,aluminium and/or zinc stearate or ricinoleate can be used.

As biogenic active substances should be understood for exampletocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid,desoxy ribonucleic acid, retinol, bisabolol, allantoin, phytantriol,panthenol, AHA acids, aminoacids, ceramides, pseudoceramides, essentialoils, extracts of plants and vitamin complexes.

As deo active agents e.g. antiperspirants such as aluminiumchlorohydrate come into question. This agent is in the form ofcolourless, hygroscopic crystals, which easily melt in air, and isobtained through evaporation of solutions of aluminium chloride inwater. Aluminium chlorohydrate is used for manufacturing of perspirationinhibiting and deodorising preparations and has probably its effectthrough the partial closure of the perspiratory gland by means ofprecipitation of proteins and/or polysaccharides [see J.Soc. Cosm. Chem.24, 281 (1973)]. Under the trade name Locron® of Hoechst AG,Frankfurt/FRG, an aluminium chlorohydrate is for example on the market,which corresponds to the formula [Al₂(OH)₅Cl].2.5 H₂O, and use of thisis especially preferred (see J. Pharm. Pharmacol. 26, 531 (1975)]. Inaddition to the chlorohydrates also aluminium hydroxylactates as well asacid aluminium/zirconium salts can be used. As further deo active agentsesterase inhibitors can be added. These are preferably trialkyl citratessuch as trimethyl citrate, tripropyl citrate, triisopropyl citrate,tributyl citrate and especially triethyl citrate (Hydagen® CAT, HenkelKGaA, DÖsseldorf/FRG). The substances inhibit the enzyme activity andthereby reduce the formation of odours. Probably the free acid isthereby set free through the cleavage of the citric acid ester, and thisacid lowers the pH value of the skin so much that the enzymes therebyare inhibited. Further substances which can be used as estersaseinhibitors are sterol sulphates or phosphates, such as for examplelanosterol, cholesterol, campesterol, stigmasterol and sitosterolsulphate or phosphate, Dicarboxylic acids and their esters, such as forexample glutaric acid, glutaric acid monoethylester, glutaric aciddiethylester, adipic acid, adipic acid monoethylester, adipic aciddiethylester, malonic acid and malonic acid diethylester,hydroxycarboxylic acids and their esters, such as for example citricacid, malic acid, tartaric acid or tartaric acid diethylester.Antibacterial active substances, which influence the germ flora and killsweat destroyng bacterias or inhibit their growth, can also be containedin the preparations. Examples of this are chitosan, phenoxyethanol andchlorohexidin gluconate. Also 5-chloro-2-(2,4-dichlorophen-oxy)phenolhas shown to have an especially good effect, and this product ismarketed under the trade name Irgasan® by Ciba-Geigy, Basel/CH.

As anti dandruff agents climbazol, octopirox and zinc pyrethion can beused. Useable film formation agents are for example chitosan,microcrystalline chitosan, quaternary chitosan, polyvinylpyrrolidon,vinylpyrrolidon/vinylacetate copolymers, polymers of the acrylic acids,quatenary derivatives of cellulose, collagen, hyaluronic acid or itssalts and similar compounds. As swelling agents for aqueous phasesmontmorillonite, day mineral substances, pemulen, as well asalkylmodified Carbopol types (Goodrich) can be used. Further suitablepolymers or swelling agents can be found in the survey of R. Lochhead inCosm. Toil. 108, 95 (1993).

UV light protection factors are e.g. organic substances (lightprotection filters) which by room temperature are in liquid orcrystalline form, and which are capable of absorbing ultravioletradiation and to set free the received energy in the form of radiationwith long wavelength, e.g. in the form of heat. UVB filters can besoluble in oils or in water. As oil soluble substances the following arementioned as examples:

3-Benzyliden camphor, respectively 3-benzylidene norcamphor and thederivatives thereof, e.g. 3-(4-methylbenzylidene) camphor as describedin EP-B1 0693471;

4-aminobenzoic acid derivatives, preferably 4-(dimethylamino) benzoicacid 2ethylhexylester, 4-(dimethylamino) benzoic acid 2-octylester and4-(dimethylamino) benzoic acid amylester;

esters of cinnamonic acid, preferably 4methoxy cinnamonic acid2-ethylhexylester, 4-methoxy cinnamonic acid propylester, 4-methoxycinnamonic acid isoamylester, 2-cyano-3,3-phenyl cinnamonic acid2-ethythexylester (octocrylene);

esters of salicylic acid, preferably salicylic acid 2-ethylhexylester,salicylic acid 4-isopropyl benzylester, salicylic acid homomenthylester;

derivatives of benzophenone, preferably 2-hydroxy4-methoxy benzophenone,2-hydroxy4-methoxy4′-methyl benzophenone, 2,2′-dihydroxy-4-methoxybenzophenone;

esters of benzalmalonic acid, preferably 4-methoxy benzmalonic acid2-ethylhexyl ester,

triazine derivatives, such as e.g.2,4,6-trianilino-(p-carbo-2′-ethyl-1′-hexyloxy)-1,3,5-triazine andoctyltriazone, as described in EP A1 0818450;

propane-1,3-diones, such as e.g.1-(4-tert.-butylphenyl)-3-(4′-methoxy-phenyl)-propane-1,3-dion;

ketotricyclo(5,2,1,0)-decane derivatives, as described in EP-B106945521. As water soluble substances the following can be mentioned:

2-Phenylbenzimidazol-5-sulphonic acid and the alkali, alkaline earth,ammonium, alkylammonium, alkanolammonium and glucammonium salts;

sulphonic acid derivatives of benzophenones, preferably2-hydroxy-4-methoxybenzophenon-5sulphonic acid and their salts;

sulphonic acid derivatives of 3-benzylidencamphen, such as e.g.4-(2-oxo-3-bornylidenmethyl)-benzene sulphonic acid and2-methyl-5-(2-oxo-bornyliden) sulphonic acid and their salts.

As typical UV-A filters especially derivatives of benzoyl methane comesin question, such as e.g.1-(4′-tert.-butylphenyl)-3-(4′-methoxyphenyl)propane-1,3-dion,4-tert.butyl-4′-methoxydibenzoyl-methane (Parsol 1789), or1-phenyl-3-(4′-isopropylphenyl-propane-1,3-dion. The UV-A and UV-Bfilters can of course also be used in mixtures. In this casecombinations of octocrylene or camphor derivatives with butylmethoxydibenzoylmethane are especially photosensitive.

In addition to the mentioned soluble substances also insoluble lightprotection pigments can be used for this purpose, i.e. fine dispersemetal oxides or salts. Examples of suitable metal oxides are especiallyzinc oxide and titanium dioxide and in addition other oxides of iron,zirconium, silicon, manganese, aluminium and cerium, as well as theirmixtures. As salts silicates (talk), barium sulphate or zinc stearatecan be used. The oxides and salts are used in the form of the pigmentsfor skin caring and skin protecting emulsions and decorative cosmetics.The particles should have an average diameter of less than 100 nm,preferably between 5 and 50 nm and especially between 15 and 30 nm. Theycan have a spherical shape, but particles can also be used which have anellipsoidal form or else have a shape which differs from the sphericalshape. In sun protecting agents preferably so-called micro or nanopigments are used. Preferably micronized zinc oxide is used.

Further suitable UV light protection factors can be found in the surveyby P. Finkel in SÖFW-Journal 122, 543 (1996). Likewise suitable areherbal extracts with UV absorbing or antioxidative properties.

In addition to the primary light protection substances also secondarylight protection substances of the antioxidant type find use, whichinterrupt the 15 photochemical reaction chain, which is initiated whenUV radiation penetrates the skin. Typical examples of such are aminoacids (e.g. glycin, histidin, tyrosin, tryptophan) and theirderivatives, imidazoles (e.g. urocaninic acid) and their derivatives,peptides such as D,L-camosine, D-camosine, L mosine and theirderivatives (e.g. anserine), carotinoides, carotine (e.g. α-carotin,β-carotin, lycopin) and their derivatives, chlorogenic acid and itsderivatives, liponic acid and its derivatives (e.g. dihydroliponicacid), aurothioglucose, propylthiouracil and other thiols (e.g.thioredoxin, glutathion, cystein, cystin, cystamine and their glycosyl,n-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl,oleyl, γ-linoleyl, cholesteryl and glyceryl esters) as well as theirsalts, dilauryl thiodipropionate, distearyl thiodipropionate,thiodipropionic acid and their derivatives (esters, ethers, peptides,lipides, nucleotides, nucleosides and salts) as well as sulfoximinecompounds (e.g. buthionin sulfoximines, homocystein sulfoximines,butionin sulfones, penta-, hexa-, hepta-thionin sufoximine) in verysmall compatible doses (e.g. pmol to μmol/kg), further (metal) chelatingagents (e.g. a-hydroxy fatty acids, palmitic acid, phytinic acid,lactoferrine), α-hydroxy acids (e.g. citric acid, lactic acid, malicacid), humin acid, gallic acid, gallic extracts, bilirubin, bifiverdin,EDTA, EGTA and their derivatives, unsaturated fatty acids and theirderivatives (e.g. γ-linolenic acid, linolic acid, oleic acid), folicacid and their derivatives, ubichinon and ubichinol and theirderivatives, vitamin C and derivatives (e.g. ascorbyl palmitate,Mg-ascorbyl phosphate, ascorbyl acetate), tocopheroles and derivatives(e.g. vitamin E acetate), vitamin A and derivatives (vitamin Apatmitate) as well as koniferyl benzoate of benzoe resin, rutinic acidand their derivatives, α-glycosylrutin, ferula acid, furfurylidenglucitol, carnosine, butylhydroxy toluene, butylhydroxy anisol,nordihydro guajak resin acid, nordihydro guajaret acid, trihydroxybutyrophenon, uric acid and their derivatives, mannose and itsderivatives, super oxide dismutase, zinc and its derivatives (e.g. ZnO,ZnSO₄), selen and its derivatives (e.g. selen-methionin), stilbenes andtheir derivatives (e.g. stilben oxide, trans-stilben oxide) and thederivatives suitable according to the invention (salts, esters, ethers,sugars, nucleotides, nucleosides, peptides and lipids) of thesementioned active substances.

For improvement of the flow properties further hydrotropes, such as forexample ethanol, isopropyl alcohol, or polyols can be used. Polyolswhich in this case can be used preferably have 2 to 15 carbon atoms andat least two hydroxyl groups. The polyols can further contain additionalfunctional groups, especially amino groups, or be modified withnitrogen. Typical examples are:

Glycerol;

alkylen glycols, such as for example ethylene glycol, diethylene glycol,propylene glycol, butylene glycol, hexylene glycol as well aspolyethylen glycols with an average molecular weight from 100 to 1 000Daltons;

oligoglycerol mixtures of technical quality with a self-condensationdegree of 1.5 to 10, such as e.g. technical quality diglycerol mixtureswith a diglycerol content of 40 to 50% by weight;

methylol compounds, such as especially trimethylol ethane, trimethylolpropane, trimethylol butane, pentaerythrite and dipentaerythrite;

low alkyl glucosides, especially such with 1 to 8 carbons in the alkylresidue, such as for example methyl and butyl glucoside;

sugar alcohols with 5 to 12 carbon atoms, such as for example sorbitolor mannitol;

sugars with 5 to 12 carbon atoms, such as for example glucose orsaccharose;

aminosugars, such as for example glucamine;

dialcoholamines, such as diethanolamine or 2-amino-1,3-propanediol.

As preservatives for example phenoxyethanol, formaldehyde solution,parabene, pentanediol or sorbic acid as well as those mentioned inenclosure 6, parts A and B of the cosmetic regulation, are furtherclasses of substances. As insect repellents N,N-diethyl-m-toluamide,1,2-pentanediol or insect repellent 3535 come into question, as selftanning agent dihydroxyacetone is suited.

As perfume oils mixtures of natural and synthetic scent substancesshould be mentioned. Natural scent substances are extracts of flowers(lilies, lavender, roses, jasmin, neroli, ylang-ylang), stems and blades(geranium, patchouli, petitgrain), fruits (anis, coriander, caraway,juniper), fruit shells (bergamot, lemon, orange), roots (macis,angelica, celery, kardamon, costus, iris, calmus), wood (stone pine,sandel, guajac, cedar, rosewood), herbs and grass (tarragon, lemongrass,sage, thyme), needles and twigs (spruce, fir, pine, traipsed), resinsand balsams (galbanum, elemi, benzoe, myrrh, olibanum, opoponax). Rawmaterials from animals are also possible, such as for example zibet andcastoreum. Typical synthetic odour compounds are products from types ofesters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Odourcompounds from types of esters are e.g. benzyl acetate, phenoxyethylisobutyrate, p-tert.-butylcyclohexyl acetate, linalyl acetate,dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate,benzyl formate, ethylmethylphenyl glycinate, allylcyclohexyl propionate,styrallyl propionate and benzyl salicylate. Benzylethyl ether belongsfor example to the ethers, to the aldehydes e.g. the linear alkanaleswith 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxy citronellal, lilial andbourgeonal, to the ketones e.g. the ionones, ∝-isomethyl ionon andmethylcedryl ketone, to the alcohols anethol, citronellol, eugenol,isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol; tothe hydrocarbons mainly the terpenes and balsams belong. However,mixtures of different odour substances are preferred, which togethergive a pleasant smell. Also etheral oils with low volatility, whichoften are used as aroma components, are suited as perfume oils, e.g.sage oil, chamomile oil, carnation oil, Melissa oil, mint oil, cinnamonleaf oil, limeflower oil, juniper berry oil, vetiver oil, oliban oil,galbanum oil, labolanum oil and lavandin oil. Preferably used arebergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethylalcohol, α-hexylcinnamon aldehyde, geranlol, benzylaceton, cyclamenaldehyde, linalool, boisambrene forte, ambroxane, indol, hedione,sandelice, lemon oil, mandarin oil, orangenoil, allylamyl glycolate,cyclovertal, lavandine oil, muskateller sage oil, β-damascone, geraniumoil bourbon, cyclohexyl salicylate, vertofix coeur, iso-E-super,fixolide NP, evemyl, iraidein gamma, phenylacetic acid, geranyl acetate,benzyl acetate, rose oxide, romillate, irotyl and floramate, alone or inmixtures.

As colouring agents such substances which are suited and approved forcosmetic purposes can be used, such as for example those mentioned inthe publication “Kosmetische Färbemittel” (cosmetic dyes) of the“Farbstoffkommission der Deutschen Forschungsgemeinschaft”, published byVerlag Chemie, Weinheim, 1984, p. 81-106. These dyes are generally usedin concentrations from 0.001 to 0.1% by weight, based on the wholemixture. Typical examples of germ inhibiting substances arepreservatives with specific effects against gram-positive bacteria, suchas 2,4,4′-trichloro-2′-hydroxy diphenylether, chlorohexidin(1.6-di-(4-chlorophenyl-biguanido-hexan) or TCC(3,4,4′-trichlorocarbanilide). Many scent substances and etheral oilsalso have antimicrobial properties. Typical examples are the activeagents eugenol, menthol and thymol in carnation, mint and thyme oil. Aninteresting natural deo substance is the terpene alcohol famesol(3,7,11-trimethyl-2,6,10-dodecatrien-1-ol), which is present in limeflower oil and has a smell of lilies of the valley. Also glycerolmonolaurate have been used as bacteriostaticum. Normally the content ofthe further germ inhibiting agent is about 0.1 to 2% by weight - basedon the solids content of the preparations,

The cumulative contents of the auxiliary and additional agents can be 1to 50, preferably 5 to 40% by weight, based on the agents. Themanufacture of the agents can take place by common cold or hotprocesses; preferably the work is carried out according to the phaseinversion temperature method.

EXAMPLES

TABLE 1 Cosmetic Preparations (water, preservatives ad 100% by weight)Composition (INCI) 1 2 3 4 5 6 7 8 9 10 Toxapon ® NSO — — — — — — 38.0 38.0  25.0  — Sodium latureth. sulphate Texapon ® SB 3 — — — — — — — —10.0  — Disodium laureth. sulphosuccinate Plantacare ® 818 — — — — — —7.0 7.0 6.0 — Coco glucosides Plantacare ® PS 10 — — — — — — — — — 16.0 Sodium laureth.sulphate (and) coco glucosides Dehyton ® PK 45 — — — — —— — — 10.0  — Cocamidopropyl betaine Dehyquart ® A 2.0 2.0 2.0 2.0 4.04.0 — — — — Centrimoniium chloride Dehyquart L ® 80 1.2 1.2 1.2 1.2 0.60.6 — — — — Dicocoylmethylethoxymonium methosulphate (and) propyleneglycol Eumulgin ® B2 0.8 0.8 — 0.8 — 1.0 — — — — Ceteareth-20 Eumulgin ®VL 75 — — 0.8 — 0.8 — — — — — Lauryl glucoside (and) polyglyceryl-2polyhydroxy stearate (and) glycerol Lanette ® O 2.5 2.5 2.5 2.5 3.0 2.5— — — — Cetearyl acohol Cutina ® GMS 0.5 0.5 0.5 0.5 0.5 1.0 — — — —Glyceryl stearate Cetiol ® HE 1.0 — — — — — — — 1.0 — PEG-7 glycerylcocoate Cetiol ® PGL — 1.0 — — 1.0 — — — — — Hexyldecanol (and)hexyldecyl laurate Cetiol ® V — — — 1.0 — — — — — — Decyl oleateEutanol ® G — — 1.0 — — 1.0 — — — — Octyldodecanol Nutrilan ® Keratin W— — — 2.0 — — — — — — Hydrolyzed keratine Lamesoft ® LMG — — — — — — 3.02.0 4.0 — Glyceryl laurate (and) potassium cocoyl hydrolyzed collagenEuperlan ® PK 3000 AM — — — — — — — 3.0 5.0 5.0 Glyceryl distearate(and) laureth.-4 (and) cocamidopropyl betaine Generol ® 122 N — — — —1.0 1.0 — — — — Soya sterol Highcareen ® GS 1.0 1.0 1.0 1.0 1.0 1.0 1.01.0 1.0 1.0 Betaglucan Desoxy ribonucleic acid 0.2 0.2 0.2 0.2 0.2 0.20.2 0.2 0.2 0.2 Molecular weight approx. 70000 Copherol ® 12250 — — 0.10.1 — — — — — — Tocopherol acetate Arlypon ® F — — — — — — 3.0 3.0 1.0 —Laureth-2 Sodium chloride — — — — — — — 1.5 — 1.5 Composition (INCI) 1112 13 14 15 16 17 18 19 20 Texapon ® NSO 20.0  20.0  12.4  — 25.0  11.0 — — — — Sodium laureth. sulphate Texapon ® K 14 S — — — — — — — — 11.0 23.0  Sodium myreth. sulphate Texapon ® SB 3 — — — — — 7.0 — — — —Disodium laureth. sulphosuccinate Plantacare ® 818 5.0 5.0 4.0 — — — — —6.0 4.0 Coco glucosldes Plantacare ® 2000 — — — — 5.0 4.0 — — — — Decylglucoside Plantacare ® PS 10 — — — 40.0  — — 16.0  17.0  — — Sodiumllaureth. sulphate (and) coco glucosides Dehyton ® PK 45 20.0 20.0 — —8.0 — — — — 7.0 Cocamidopropyl betaine Eumulgin ® B2 — — — 1.0 1.0 — — —— — Ceteareth-20 Lameform ® TGI — — — 4.0 — — — — — — Polyglyceryl-3isostearate Dehymuls ® PGPH — — 1.0 — — — — — — — Polyglyceryl-2dipolyhydroxy stearate Monomuls ® 90-L 12 — — — — — — — — — 1.0 Glyceryllaurate Cutina ® GMS — — — — — — — — 1.0 — Glyceryl stearate Cetiol ® HE— 0.2 — — — — — — — — PEG-7 Glyceryl cocoate Eutanol ® G — — — 3.0 — — —— — — Octyldodecanol Nutrilan ® Keratin W — — — — — — — — 2.0 2.0Hydrolyzed keratin Nutrilan ® I 1.0 — — — — 2.0 — 2.0 — — Hydrolyzedcollagen Lamesoft ® LMG — — — — — — — — 1.0 — Glyceryl laurate (and)potassium cocoyl hydrolyzed collagen Lamesoft ® 156 — — — — — — — — —5.0 Hydrogenated tallow glyceride (and) potassium cocoyl hydrolyzedcollagen Gluadin ® WK 1.0 1.5 4.0 1.0 3.0 1.0 2.0 2.0 2.0 — Sodiumcocoyl hydrolyzed wheat protein Euperlan ® PK 3000 AM 5.0 3.0 4.0 — — —— 3.0 3.0 — Glycol distearate (and) laureth-4 (and) cocamidopropylbetaine Panthenol — — 1.0 — — — — — — — Highcareen ® GS 1.0 1.0 1.0 1.01.0 1.0 1.0 1.0 1.0 1.0 Betaglucan Desoxy ribonucleic acid 0.2 0.2 0.20.2 0.2 0.2 0.2 0.2 0.2 0.2 Molecular weight approx. 70000 Arlypon ® F2.6 1.6 — 1.0 1.5 — — — — — Laureth-2 Sodium chloride — — — — — 1.6 2.02.2 — 3.0 Glycerol (86% by weight) — 5.0 — — — — — 1.0 3.0 — Composition(INCI) 21 22 23 24 25 26 27 28 29 30 Texapon ® NSO — 30.0  30.0  — 25.0 — — — — — Sodium laureth. sulphate Plantacare ® 818 — 10.0  — — 20.0  —— — — — Coco glucosides Plantacare ® PS 10 22.0  — 5.0 22.0  — — — — — —Sodium laureth. sulphate (and) coco glucosides Dehyton ® PK 45 15.0 10.0  15.0  15.0  20.0  — — — — — Cocamidopropyl betaine Emulgade ® SE —— — — — 5.0 5.0 4.0 — — Glyceryl stearate (and) ceteareth. 12/20 (and)cetearyl alcohol (and) cetylpalmitate Eumulgin ® B1 — — — — — — — 1.0 —— Ceteareth-12 Lameform ® TGI — — — — — — — — 4.0 — Polyglyceryl-3isostearate Dehymuls ® PGPH — — — — — — — — — 4.0 Polyglyceryl-2dipolyhydroxystearate Monomuls ® 90-O 18 — — — — — — — — 2.0 — Glyceryloleate Cetiol ® HE 2.0 — — 2.0 5.0 — — — — 2.0 PEG-7 Glyceryl cocoateCetiol ® OE — — — — — — — — 5.0 6.0 Dicaprylyl ether Cetiol ® PGL — — —— — — — 3.0 10.0  9.0 Hexyldecanol (and) hexyldecyl laurate Cetiol ® SN— — — — — 3.0 3.0 — — — Cetearyl isononanoate Cetiol ® V — — — — — 3.03.0 — — — Decyl oleate Myritol ® 318 — — — — — — — 3.0 5.0 5.0 Cococaprylate caprate Bees Wax — — — — — — — — 7.0 5.0 Nutrilan ® ElastinE20 — — — — — 2.0 — — — — Hydrolyzed elastin Nutrilan ® I-50 — — — — 2.0— 2.0 — — — Hydrolyzed collagen Gluadin ® AGP 0.5 0.5 0.5 — — — — 0.5 —— Hydrolyzed wheat glutene Gluadin ® WK 2.0 2.0 2.0 2.0 5.0 — — — 0.50.5 Sodium cocoyl hydrolyzed wheat protein Eupertan ® PK 3000 AM 5.0 — —5.0 — — — — — — Glycol distearate (and) laureth-4 (and) cocamidopropylbetaine Highcareen ® GS 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0Betaglucan Desoxy ribonucleic acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.20.2 Molecular weight approx. 70000 Magnesium sulphate heptahydrate — — —— — — — — 1.0 1.0 Glycerol (86% by weight) — — — — — 3.0 3.0 5.0 5.0 3.0Composition (INCI) 31 32 33 34 35 36 37 38 39 40 Dehymul ® PGPH 4.0 3.0— 5.0 — — — — — — Polyglyceryl-2 dipolyhydroxystearate Lameform ® TGI2.0 1.0 — — — — — — — — Polyglyceryl-3 diisostearate Emulgade ® PL 68/50— — — — 4.0 — — — 3.0 — Cetearyl glucoside (and) cetearyl alcoholEumulgin ® B2 — — — — — — — 2.0 — — Ceteareth-20 Tegocare ® PS — — 3.0 —— — 4.0 — — — Polyglyceryl-3 methylglucose distearate Eumulgin VL75 — —— — — 3.5 — — 2.5 — Polyglyceryl-2 dipolyhydroxystearate (and) laurylglucoside (and) glycerol Beeswax 3.0 2.0 5.0 2.0 — Cutina ® GMS — — — —— 2.0 4.0 — — 4.0 Glyceryl stearate Lanette ® O — — 2.0 — 2.0 4.0 2.04.0 4.0 1.0 Cetearyl alcohol Antaron ® V 216 — — — — — 3.0 — — — 2.0PVP/hexadecene copolymer Myritol ® 818 5.0 — 10.0  — 8.0 6.0 6.0 — 5.05.0 Coco glycerides Finsolv ® TN — 6.0 — 2.0 — — 3.0 — 2.0 C12/15 Alkylbenzoate Cetiol ® J 600 7.0 4.0 3.0 5.0 4.0 3.0 3.0 — 5.0 4.0 Oleylerucate Cetiol ® OE 3.0 — 6.0 8.0 6.0 5.0 4.0 3.0 4.0 6.0 Dicaprylylether Mineral Oil — 4.0 — 4.0 — 2.0 — 1.0 — — Cetiol ® PGL — 7.0 3.0 7.04.0 — — — 1.0 — Hexadecenol (and) hexyl laurate Pantheriol/Bisabolol 1.21.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Hlghcareen ® GS 1.0 1.0 1.0 1.0 1.01.0 1.0 1.0 1.0 1.0 Betaglucan Desoxy ribonucleic acid 0.2 0.2 0.2 0.20.2 0.2 0.2 0.2 0.2 0.2 Molecular weight approx. 70000 Copherol ® F 13000.5 1.0 1.0 2.0 1.0 1.0 1.0 2.0 0.5 2.0 Tocopherol/tocopheyl acetate NeoHeliopan ® Hydro 3.0 — — 3.0 — — 2.0 — 2.0 — Sodium phenylbenzimidazoiesulphonate Neo Heliopan ® 303 — 5.0 — — — 4.0 5.0 — — 10.0  OctocryleneNeo Hehopan ® BB 1.5 — — 2.0 1.5 — — — 2.0 — Benzophenone-3 NeoHeliopan ® E 1000 5.0 — 4.0 — 2.0 2.0 4.0 10.0  — — Isoamylp-metoxycinnamate Neo Heliopan ® AV 4.0 — 4.0 3.0 2.0 3.0 4.0 — 10.0 2.0 Octyl metoxycinnamate Uvinul ® T 150 2.0 4.0 3.0 1.0 1.0 1.0 4.0 3.03.0 3.0 Octyl triazone Zinc oxide — 6.0 6.0 — 4.0 — — — — 5.0 Titaniumdioxide — — — — — — — 5.0 — — Glycerol (86% by weight) 5.0 5.0 5.0 5.05.0 5.0 5.0 5.0 5.0 5.0 (1-4) Hair rinsing, (5-6) Hair cure, (7-8)Shower bath, (9) Shower gel, (10) Cleaning lotion (11-14) Shower bath“two-in-one”. (15-20) Shampoo (21-25) Foam bath, (26) Soft creme,(27-28) Moisture emulsion, (29-30) Night creme (31) W/O Sun protectioncreme, (32-34) W/O Sun protection lotion, (35, 38, 40) O/W Sunprotection lotion (36, 37, 39) O/W Sun protection creme

We claim:
 1. Cosmetic and/or pharmaceutical preparations comprising a)water soluble β-(1,3) glucans, free from repetitive β-(1,6) linkages,and b) (desoxy)ribonucleic acids, as well as their cleavage anddegradation products.
 2. The preparations according to claim 1, whichcomprise glucans which are obtained by contacting glucans with β-(1,3)and β-(1,6) linkages with β-(1,6) glucanases, in such a way that allβ-(1,6) linkages are loosened apart from those chains of four or lessβ-(1,6)-bound glucose units.
 3. The preparations according to claim 1,which contain marine (desoxy)ribonucleic acids.
 4. The preparationsaccording to claim 1, which contain (desoxy)ribonucleic acids with amolecular weight in the area of 40, 000 to 1,000,000.
 5. Thepreparations according to claim 1, which comprise UV light protectionfactors.
 6. The preparations according to claim 1, which comprise a)0.01 to 25% by weight of water soluble β-(1,3) glucans, which aresubstantially free from β-(1,6) linkages, b) 0.01 to 5% by weight of(desoxy)ribonucleic acid as well as its cleavage and decompositionproducts, and c) 0 to 8% by weight of UV light protection factors,respectively antioxidants, provided that the stated amounts aresupplemented with water as well as optionally other auxiliaries andadditional agents up 100% by weight.